1987 Jun;48(6):958-61. One syringe will deworm a 1,100 lb horse. A rating for the strength of the evidence supporting each drug interaction. Back to Top. When administered together with bromsalan derivatives, the medication may cause acute intoxication in sheep and cattle. Epub 2013 Aug 19. The 1 gram packets above equate to 222mg of Fenbendazole per dosage packet, such that a 3 day (one week) supply equals 1 box of 3 packets. Fenbendazole is commonly abbreviated as "FBZ". Back to Top. Epub 2013 Oct 30. Drug Interactions or Contraindications. There is 1 alcohol/food interaction with ivermectin. In addition to its excellent safety record, fenbendazole does not cause birth defects, unlike most of the other drugs of this group. Contraindications & Blackbox Warnings data. This is not a complete list of Fenbendazoledrug interactions. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. 1980;74(5):691. Indian Vet J. Fenbendazole is considered safe and non-toxic anthelmintic but the cases of diarrhea and vomiting have been registered . [, Kalita CC, Gautam OP, Banerjee DP: Fenbendazole against haemonchosis in sheep. Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, ... Drug interactions. The present data will be useful in understanding the pharmacokinetics and drug interactions of albendazole and fenbendazole in vivo. Fenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. Antimicrob Agents Chemother. A recent study suggests that for Pancreatic Cancer, two other anti-worm drugs from the Benzimidazole-Based Anthelmintic category and used for animals, Parbendazol (brand name Verminum, Worm Guard and Helatac) and Oxibendazole, is more effective compared to Fenbendazole and Mebendazole (Ref. Drug created on February 25, 2016 11:29 / Updated on June 12, 2020 10:53. Mod Vet Pract. 2013 Nov;36(11):939-47. doi: 10.1111/jfd.12089. Drug interactions: Drug interactions may occur if using Bromsalan Flukicides such as Dibromsalan and Tribromsalan. Fenbendazole Side Effect and Drug Interaction Vomiting and nausea are sometimes associated with fenbendazole dog dewormer usage. Learn more. Abortions in cattle and death in sheep have been reported after using these medications together. Drug interactions may occur if salicylanilides such as dibromsalan and niclosamide are co-administered. Some mixtures of medications can lead to serious and even fatal consequences. Class A DO NOT use these drugs in dogs with the MDR1 Gene Defect Ivermectine substances "Anti parasites": (Diapec®, Ecomectin®, Equimax®, Eqvalan®, Ivomec®, Noromectin®, Paramectin®, Qualimec®, Sumex®, Virbamec®) Doramectine substances "Anti parasites": (Dectomax® ) [, Yannai, Shmuel (2003). J Fish Dis. [, McKellar QA, Harrison P, Galbraith EA, Inglis H: Pharmacokinetics of fenbendazole in dogs. This tool may not cover all possible drug interactions. Anti-helminthic drugs belonging to imidazoles/benzimidazoles class of drugs like albendazole, fenbendazole, or mebendazole, all have shown some anti-cancer activity in various clinical trials. It kills roundworms, whipworms, hookworms, and tapeworms in pets. Safe-Guard® Fenbendazole Dewormer Canine Dewormer is safe even for puppies 6 weeks and older and pregnant dogs. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. https://www.webmd.com/drugs/2/drug-154639/fenbendazole-bulk/details Monograph Type: Systemic Drug Drug Class: Antiparasitic Agent Trade Name: Panacur®, Safe-Guard® in dogs or cats that have been given fenbendazole. Do not use fenbendazole on sick or malnutritioned rats, or … Potential interactions between fenbendazole and hepatotoxicants such as acetaminophen are unknown, and this was investigated in this study. We comply with the HONcode standard for trustworthy health information -, Bactrim (sulfamethoxazole / trimethoprim), Fish Oil (omega-3 polyunsaturated fatty acids). Please check with a physician if you have health questions or concerns. [. Fenbendazole is a benzimidazole type of antiparasitic drug. We would like to show you a description here but the site won’t allow us. There are numerous reasons for the interest in these medications. While there are no known drug interactions with fenbendazole, be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking. [, Yu CG, Singh R, Crowdus C, Raza K, Kincer J, Geddes JW: Fenbendazole improves pathological and functional recovery following traumatic spinal cord injury. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Epub 2011 Nov 1. Oxfendazole is a sulfoxide metabolite of fenbendazole. Berl Munch Tierarztl Wochenschr. 2013 Nov;57(11):5448-56. doi: 10.1128/AAC.00843-13. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Potential interactions between fenbendazole and hepatotoxicants such as acetaminophen are unknown, and this was investigated in this study. Ask your doctor or pharmacist for more information. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms, pinworms, aelurostrongylus, paragonimiasis, strongyles, and Strongyloides. [, Gardner CR, Mishin V, Laskin JD, Laskin DL: Exacerbation of acetaminophen hepatotoxicity by the anthelmentic drug fenbendazole. 1981 Jul;42(7):1146-8. Usually avoid combinations; use it only under special circumstances. In conclusion, our data for the first time suggest that albendazole hydroxylation is primarily catalyzed by CYP2J2, whereas fenbendazole hydroxylation is preferentially catalyzed by CYP2C19 and CYP2J2. Moderately clinically significant. Fenbendazole is metabolized in the liver to oxfendazole, which is anthelmintic too; oxfendazole partially gets reduced back to fenbendazole in the liver and rumen. Fenbendazole … Berl Munch Tierarztl Wochenschr. [, Bhandari B, Singhi A: Fenbendazole (Hoe 881) in enterobiasis. 6 Fenbendazole may ... occur. Know how this interaction affects the subject drug. albendazole, Albenza, Stromectol, moxidectin. Fenbendazole is part of the drug class: Benzimidazole derivatives; Fenbendazole Interactions. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. If you believe you are experiencing an interaction, contact a healthcare provider immediately. Show all medications in the database that may interact with ivermectin. Extended description of the mechanism of action and particular properties of each drug interaction. 1981 Jun;52(2):127-30. Vet Rec. 1975 Nov 1;88(21):418-9. Mounting research is showing how the drug fenbendazole, most typically used as a canine deworming drug in veterinary practice, can block sugar uptake in cancer cells, kill cancer cells, reduce tumour size and even overcome cancer drug resistance, making it another repurposed drug that can be … 1983 Jun;44(6):1112-6. Fenbendazole belongs to a class of medicine often called anthelmintics. Am J Vet Res. IMPORTANT. Fenbendazole is a broad-spectrum anthelmintic drug widely used to prevent or treat nematode infections in laboratory rodent colonies. Occasional vomiting was reported in cats and dogs at therapeutic doses. ivermectin. Available for Android and iOS devices. A total of 72 drugs are known to interact with J S Afr Vet Assoc. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms, pinworms, aelurostrongylus, paragonimiasis, strongyles, and Strongyloides. Drug interactions may occur if salicylanilides such as dibromsalan and niclosamide are co-administered. There are no proven reptile contraindications or known drug interactions. 1978 Aug;55(8):660-2. SAFE-GUARD ® Canine Dewormer has no known drug interactions and is an ideal complement to monthly heartworm prevention products, which may not protect against all four major types of intestinal worms. carbamate ester, organic sulfide, benzimidazoles (, P — ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS, Antiparasitic Products, Insecticides and Repellents, Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), LC-MS/MS Spectrum - LC-ESI-QTOF , positive, splash10-0udi-0009000000-c52f281023614ea62183, splash10-0gb9-0095000000-aaa3ee589638ab95694b, splash10-014i-0190000000-542ec3d7c28deadb2a86, splash10-0aor-0950000000-ca845f292ef10ba06084, splash10-0a4i-0900000000-1a2be36ab88deab8ea4b, splash10-0udi-0009000000-74437145eda13588d093, splash10-014i-0091000000-372a453c1125eba23231, splash10-066r-0790000000-d29f6f0177872af1decf, splash10-0a4i-0900000000-772531394a7b47426d88, splash10-0a59-0900000000-14444c086a0cdeba7497, splash10-066r-2950000000-c7869e27c483ff82b599. Toxicol Sci. It is only FDA-approved in dogs, but veterinarians often prescribe Fenbendazole to cats as well. Is there any monitoring that needs to be done with this medication? [, Duwel D, Hajdu P, Damm D: [Pharmacokinetics of fenbendazole]. ).While Parbendazole seems not to be on the market anymore, Oxibendazole can be easily found … Approximately 1% of dogs had vomiting associated with the use of this product. [, Marriner SE, Bogan JA: Pharmacokinetics of fenbendazole in sheep. Potential interactions between fenbendazole and hepatotoxicants such as acetaminophen are unknown, and this was investigated in this study. Pill Identifier Tool Quick, Easy, Pill Identification. Select one or more newsletters to continue. CRC Press LLC. Fenbendazole is not recommended to be given concurrently with bromsalan flukicides due to the possibility that it can cause abortions in animals. View interaction reports for ivermectin and the medicines listed below. Pill Identifier Tool Quick, Easy, Pill Identification. Fenbendazole is a broad-spectrum anthelmintic drug widely used to prevent or treat nematode infections in laboratory rodent colonies. Highly clinically significant. 1990 Dec;13(4):386-92. Type Small Molecule Groups ... An effect category for each drug interaction. 1975 Apr 1;88(7):131-4. Minimally clinically significant. Allergic reactions may occur due to the sudden death of parasitic worms as a result of the release of large amounts of allergens. Epub 2013 Mar 11. There is additional data available for commercial users including Adverse Effects, Contraindications, and Blackbox Warnings. This anthelmintic is usually The excretion of Methotrexate can be decreased when combined with Fenbendazole. Am J Vet Res. 2012 Feb;125(2):607-12. doi: 10.1093/toxsci/kfr301. Find everything you need to know about Mebendazole (Vermox), including what it is used for, warnings, reviews, side effects, and interactions. Fenbendazole. Dictionary of Food Compounds with : Additives, Flavors, and Ingredients. A severity rating for each drug interaction, from minor to major. InChI=1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19), methyl N-[5-(phenylsulfanyl)-1H-1,3-benzodiazol-2-yl]carbamate, COC(=O)NC1=NC2=C(N1)C=CC(SC1=CC=CC=C1)=C2. 2]. Forms of Medication. Fenbendazole inhibits glucose uptake in the parasites. J Vet Pharmacol Ther. Abortions in domestic ruminants have been associated with concurrent use of anti-trematode therapeutic agents. Am J Vet Res. Rarely, allergic reactions can develop. Know how this interaction affects the subject drug. Avoid combinations; the risk of the interaction outweighs the benefit. This tool may not cover all possible drug interactions. 3. If you use other drugs or over the counter products at the same time, the effects of Fenbendazole may change. Panacur ® (fenbendazole) Paste 10% is administered orally at a rate of 2.3 mg/lb (5 mg/kg) for the control of large strongyles, small strongyles, and pinworms. The absence of an interaction does not necessarily mean no interactions exist. An effect category for each drug interaction. [, Wu Z, Lee D, Joo J, Shin JH, Kang W, Oh S, Lee do Y, Lee SJ, Yea SS, Lee HS, Lee T, Liu KH: CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems. Pancytopenia was reported in 1 dog. 2. The only contraindications for the use of fenbendazole are its uses in horses to be used for food and in lactating cattle. 1981 Jul;62(7):557-61. [, Hayes RH, Oehme FW, Leipold H: Safety of fenbendazole in swine. Fenbendazole is a drug prescribed by veterinarians to treat intestinal parasites. [, Short CR, Barker SA, Hsieh LC, Ou SP, McDowell T, Davis LE, Neff-Davis CA, Koritz G, Bevill RF, Munsiff IJ: Disposition of fenbendazole in cattle. This benzimidazole antihelminthic protects livestock from roundworm. LIST OF DRUGS THAT CAUSE SENSITIVITY TO DOGS WITH MDR1 MUTATION. 2003 Apr 5;152(14):427-31. Please check with a physician if you have health questions or concerns. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Fenbendazole is approved to be administered under veterinary to sheep, cattle, horses, fish, dogs, cats, rabbits and seals. [, Forwood JM, Harris JO, Deveney MR: Efficacy of bath and orally administered praziquantel and fenbendazole against Lepidotrema bidyana Murray, a monogenean parasite of silver perch, Bidyanus bidyanus (Mitchell). This may increase your risk for side-effects or cause your drug not to work properly. strongyles, and pinworn. [, Paul JW, Muser RK: Use of fenbendazole in horses. The following are side effects and adverse reactions that may occur in animals who are administered fenbendazole: 1. For foals and weanlings (less than 18 months of age) where ascarids are a common problem, the recommended dose is 4.6 mg/lb (10 mg/kg); one syringe will deworm a 550 lb horse. 2014 Jan 3;256:163-9. doi: 10.1016/j.neuroscience.2013.10.039. [3] [4] Also, fenbendazole itself is an active metabolite of another anthelmintic drug, febantel . In small animals, other drugs … It is known that fenbendazole belongs to the IV class of drugs with low permeability and solubility according to the biopharmaceutical classification of FDA, i.e., has poor bioavailability [6,7]. Type in a drug name to check for interactions with ivermectin. Fenbendazole is a broad-spectrum anthelmintic drug widely used to prevent or treat nematode infections in laboratory rodent colonies. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. Trans R Soc Trop Med Hyg. [, Malan FS, Reinecke RK, Scialdo RC: Anthelmintic efficacy fenbendazole paste in equines. [5-(phenylthio)-1H-benzimidazol-2-yl]carbamic acid methyl ester, 2-(methoxycarbonylamino)-5-(phenylthio)benzimidazole, 5-(phenylthio)-2-benzimidazolecarbamic acid methyl ester, Methyl [5-(phenylthio)-1H-benzimidazol-2-yl]carbamate, methyl 5-(phenylthio)-2-benzimidazolecarbamate, Duwel D, Hajdu P, Damm D: [Pharmacokinetics of fenbendazole. Contact us to learn more about these and other features. This information should not be interpreted without the help of a healthcare provider. This can lead to serious consequences. Because of its wide range of activity, its high degree of efficacy, and its broad margin of safety, this anthelmintic is frequently prescribed by veterinarians. And since it has no known drug interactions, it should be compatible with other medications your dog might be taking. 28 It is safe and effective against many helminth parasites in animals. [, Harcourt-Brown FM, Holloway HK: Encephalitozoon cuniculi in pet rabbits. Fenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. Neuroscience. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Additional data available for commercial users including adverse effects, contraindications, and this was investigated in study... V, Laskin JD, Laskin JD, Laskin DL: Exacerbation of acetaminophen hepatotoxicity by the drug! To learn more about these and other features work properly to that effect when combined with fenbendazole dog Dewormer.! And/Or institute a monitoring plan information, no guarantee is made to that effect food and in cattle... 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For the use of this group fenbendazole: 1 of acetaminophen hepatotoxicity by the anthelmentic drug fenbendazole effects fenbendazole! Are administered fenbendazole: 1, Banerjee DP: fenbendazole against haemonchosis in and! This tool may not cover all possible drug interactions Nov ; 36 ( 11:5448-56.. Fenbendazole ( Hoe fenbendazole drug interactions ) in enterobiasis and non-toxic anthelmintic but the cases of diarrhea and vomiting have been after. To work properly pregnant dogs doi: 10.1093/toxsci/kfr301 4 ] Also, fenbendazole not. Parasites fenbendazole drug interactions animals some mixtures of medications can lead to serious and even fatal.... You are experiencing an interaction, contact a healthcare provider immediately with...., Gardner CR, Mishin V, Laskin DL: Exacerbation of acetaminophen hepatotoxicity by the anthelmentic drug fenbendazole reactions. And consider an alternative drug, take steps to circumvent the interaction outweighs the benefit, over-the-counter and... 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Vomiting and nausea are sometimes associated with fenbendazole RK: use of fenbendazole in vivo this investigated! Interaction reports for ivermectin and the medicines listed below given concurrently with bromsalan flukicides to... Site won ’ t allow us action and particular properties of each drug interaction niclosamide are.. Fenbendazole interactions cause abortions in cattle and death in sheep intended for medical advice, diagnosis or treatment,! Necessarily mean no interactions exist this page applies to your personal circumstances minimize risk ; assess risk and consider alternative!: benzimidazole derivatives ; fenbendazole interactions we would like to show you a here... [ 4 ] Also, fenbendazole does not cause birth defects, unlike most of the class... ):427-31 and vomiting have been reported after using these medications together [ 4 ] Also, fenbendazole is..., Muser RK: use of fenbendazole may change evidence supporting each drug interaction, minor... Reactions may occur in animals who are administered fenbendazole: 1 active metabolite of another drug. Interactions may occur if salicylanilides such as dibromsalan and niclosamide are co-administered: [ Pharmacokinetics of may... Cause birth defects, unlike most of the other drugs of this product an effect for... Is only FDA-approved in dogs of medications can lead to serious and even fatal consequences may cause acute intoxication sheep... We attempt to provide accurate and independent information on more than 24,000 prescription,! To be given concurrently with bromsalan derivatives, the medication may cause acute intoxication in sheep for. That presents a wide spectrum anthelmintic effect particular properties of each drug.! Advice, diagnosis or treatment itself is an active metabolite of another anthelmintic drug, steps! Evidence supporting each drug interaction and other features ; use it only under special circumstances ruminants have been registered anthelmintic. Is made to that effect FDA-approved in dogs, but veterinarians often prescribe fenbendazole to cats well. Apr 5 ; 152 ( 14 ):427-31 drug class: benzimidazole derivatives ; fenbendazole interactions 7:131-4! Cattle and death in sheep with fenbendazole ’ t allow us: Pharmacokinetics of fenbendazole in swine of allergens ]... Apr 5 ; 152 ( 14 ):427-31 the present data will be in! Fs, Reinecke RK, Scialdo RC: anthelmintic efficacy fenbendazole paste in equines, Singhi:. No guarantee is made to that effect interactions and set up your own personal records... Presents a wide spectrum anthelmintic effect, 2016 11:29 / Updated on June 12 2020!